Measurement of paved road surface profile.

A road less traveled paved by IDO silencing

Orchestrating a cytotoxic polymorphonuclear neutrophil (PMN) response strictly focused within the tumor tissue remains a formidable challenge for the successful therapeutic use of these cells. A Salmonella vector carrying an shRNA against indoleamine 2,3-dioxygenase has been shown to recruit PMNs and enhance their activation specifically in the tumor bed, resulting in significant anticancer eff...

The Road to Frailty Is Paved With Good Intentions.

Frailty is a relatively young area of investigation in cardiovascular research. The first wave of published research, circa 2001 to 2006, uncovered the epidemiological and pathophysiological links between frailty and cardiovascular disease (CVD). Compared to those without CVD, older adults with CVD were reported to have an odds ratio of 2.7 to 4.1 for prevalent frailty in cross-sectional studie...

The Road to Unintended Consequences Is Paved With Good Intentions.

1100 www.ccmjournal.org June 2017 • Volume 45 • Number 6 immune activation by cytokine-expression in the muscle tissue. J Neuroimmunol 2000; 106:206–213 6. Gleeson M, Bishop NC, Stensel DJ, et al: The anti-inflammatory effects of exercise: Mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 2011; 11:607–615 7. Drummond MJ, Timmerman KL, Markofski MM, et al: ...

Digital Auctions: Mapping the IT-Paved Road towards Market Efficiency

IT enables a more smooth performance of entire business exchanges. Hence it has the potential to alter market efficiency. Our paper addresses the question whether market efficiency is realized differently in a digital market setting as opposed to analog auctions. In addition, the paper will explore whether it is more likely that market efficiency will improve in the digital auction setting than...

Is an Automaker’s Road to Bankruptcy Paved with Customers’ Beliefs?